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Welcome to Kasahara Lab@NTU, Singapore


We are part of the Nutrition, Metabolism and Health Programme and the Microbiome Medicine Programme at the Lee Kong Chian School of Medicine, Nanyang Technological University in Singapore.

Research in the lab is focused on discovering novel diet-microbiome-host interactions that affect cardiometabolic diseases. We are interested in designing gut microbiota-targeted interventions for prevention and treatment of non-communicable diseases.


We are located in CSB (Clinical Sciences Building) at the Novena Campus of LKCMedicine, NTU.

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Research

Human studies have revealed consistent alterations in the gut microbiomes of patients with cardiometabolic and aging-associated diseases. A major focus of our group is to understand how variations in the gut microbiome modulate the effects of diet and host’s susceptibility to cardiometabolic disease.

In the Kasahara laboratory at LKCMedicine, Nanyang Technological University, we are applying experimental and computational tools to understand the interactions between diet, the microbiota, and human health with an emphasis on cardiometabolic disorders including atherosclerosis and non-alcoholic fatty liver disease.

Latest Publications

Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization

Mol Cell. 2026 Apr 23;S1097-2765(26)00232-7. doi: 10.1016/j.molcel.2026.03.036.

We mapped over 100,000 liver cis-regulatory elements in human hepatocytes under both in vitro and in vivo conditions. Our results reveal that gut microbiota–derived signals, including microbial metabolites, directly regulate liver gene expression by modulating regulatory elements, partly through the KEAP1/NFE2L2 pathway. This study highlights a microbiota-dependent layer of gene regulation in the human liver.

Does.Variety.In.Your.Diet.Equal.Variety.In.Your.Gut.Microbiome_16x9_d369f2ea-4215-4577-8b2

11 Mandalay Rd, Singapore 308232

kasaharalab.com

kazuyuki.kasahara at ntu.edu.sg

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