Publications

Gut bacterial metabolism contributes to host global purine homeostasis

Kasahara K, Kerby RL, Zhang Q, Pradhan M, Mehrabian M, Lusis AJ, Bergström G, Bäckhed F, Rey F. Cell Host Microbe. 2023.

Dissecting the impact of dietary fiber type on atherosclerosis in mice colonized with different gut microbial communities

Hutchison ER, Kasahara K, Zhang Q, Vivas EI, Cross TWL, Rey FE. NPJ Biofilms Microbiomes. 2023.

Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut

Zhang Q, Linke V, Overmyer KA, Traeger LL, Kasahara K, Miller IJ, Manson DE, Polaske TJ, Kerby RL, Kemis JH, Trujillo EA, Reddy TR, Russell JD, Schueler KL, Stapleton DS, Rabaglia ME, Seldin M, Gatti DM, Keele GR, Pham DT, Gerdt JP, Vivas EI, Lusis AJ, Keller MP, Churchill GA, Blackwell HE, Broman KW, Attie AD, Coon JJ, Rey FE. Nat Microbiol. 2023.

Gut microbiota and diet matrix modulate the effects of the flavonoid quercetin on atherosclerosis

Kasahara K, Kerby RL, Cross TW, Everhart J, Colin C, Bolling B, Bäckhed F, Rey F. Res Sq. 2023.

The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass

Debédat J, Le Roy T, Voland L, Belda E, Alili R, Adriouch S, Bel Lassen P, Kasahara K, Hutchison E, Genser L, Torres L, Gamblin C, Rouault C, Zucker JD, Kapel N, Poitou C, Marcelin G, Rey FE, Aron-Wisnewsky J, Clément K. Gut Microbes. 2022 Jan-Dec;14(1):2050635. doi: 10.1080/19490976.2022.2050635.

Depletion of Foxp3+ regulatory T cells augments CD4+ T cell immune responses in atherosclerosis-prone hypercholesterolemic mice

Kasahara K, Sasaki N, Amin HZ, Tanaka T, Horibe S, Yamashita T, Hirata KI, Rikitake Y. Heliyon. 2022 Jul 19;8(7):e09981. doi: 10.1016/j.heliyon.2022.e09981. eCollection 2022 Jul.

The emerging role of gut microbial metabolism on cardiovascular disease

Kasahara K, Rey FE. Curr Opin Microbiol. 2019 Aug;50:64-70. doi: 10.1016/j.mib.2019.09.007.

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model

Kasahara K, Krautkramer KA, Org E, Romano KA, Kerby RL, Vivas EI, Mehrabian M, Denu JM, Bäckhed F, Lusis AJ, Rey FE. Nat Microbiol. 2018 Dec;3(12):1461-1471. doi: 10.1038/s41564-018-0272-x. Epub 2018 Nov 5.

Sexual dimorphism of cardiometabolic dysfunction: Gut microbiome in the play?

Cross TL, Kasahara K, Rey FE. Mol Metab. 2018 Sep;15:70-81. doi: 10.1016/j.molmet.2018.05.016.

Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation

Romano KA, Dill-McFarland KA, Kasahara K, Kerby RL, Vivas EI, Amador-Noguez D, Herd P, Rey FE. Microbiome. 2018 May 18;6(1):91. doi: 10.1186/s40168-018-0458-8.

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Romano KA, Martinez-Del Campo A, Kasahara K, Chittim CL, Vivas EI, Amador-Noguez D, Balskus EP, Rey FE. Cell Host Microbe. 2017 Sep 13;22(3):279-290.e7. doi: 10.1016/j.chom.2017.07.021.

Ultraviolet B Exposure Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Expanding CD4+Foxp3+ Regulatory T Cells

Hayashi T, Sasaki N, Yamashita T, Mizoguchi T, Emoto T, Amin HZ, Yodoi K, Matsumoto T, Kasahara K, Yoshida N, Tabata T, Kitano N, Fukunaga A, Nishigori C, Rikitake Y, Hirata KI. J Am Heart Assoc. 2017 Aug 31;6(9):e007024. doi: 10.1161/JAHA.117.007024.

Oral administration of the lactic acid bacterium Pediococcus acidilactici attenuates atherosclerosis in mice by inducing tolerogenic dendritic cells

Mizoguchi T#, Kasahara K#, Yamashita T, Sasaki N, Yodoi K, Matsumoto T, Emoto T, Hayashi T, Kitano N, Yoshida N, Amin HZ, Hirata KI. # equally contributed. Heart Vessels. 2017 Jun;32(6):768-776. doi: 10.1007/s00380-017-0949-8. Epub 2017 Feb 8.

Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis

Kasahara K, Tanoue T, Yamashita T, Yodoi K, Matsumoto T, Emoto T, Mizoguchi T, Hayashi T, Kitano N, Sasaki N, Atarashi K, Honda K, Hirata KI. J Lipid Res. 2017 Mar;58(3):519-528. doi: 10.1194/jlr.M072165. Epub 2017 Jan 27.

Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease

Emoto T, Yamashita T, Kobayashi T, Sasaki N, Hirota Y, Hayashi T, So A, Kasahara K, Yodoi K, Matsumoto T, Mizoguchi T, Ogawa W, Hirata KI. Heart Vessels. 2017 Jan;32(1):39-46. doi: 10.1007/s00380-016-0841-y. Epub 2016 Apr 28.

UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses

Sasaki N, Yamashita T, Kasahara K, Fukunaga A, Yamaguchi T, Emoto T, Yodoi K, Matsumoto T, Nakajima K, Kita T, Takeda M, Mizoguchi T, Hayashi T, Sasaki Y, Hatakeyama M, Taguchi K, Washio K, Sakaguchi S, Malissen B, Nishigori C, Hirata KI. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):66-74. doi: 10.1161/ATVBAHA.116.308063. Epub 2016 Oct 20.

Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease

Emoto T, Yamashita T, Sasaki N, Hirota Y, Hayashi T, So A, Kasahara K, Yodoi K, Matsumoto T, Mizoguchi T, Ogawa W, Hirata K. J Atheroscler Thromb. 2016 Aug 1;23(8):908-21. doi: 10.5551/jat.32672.

Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice

Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata K. Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1141-51. doi: 10.1161/ATVBAHA.115.306848. Epub 2016 Apr 7.

Intestinal Immunity and Gut Microbiota as Therapeutic Targets for Preventing Atherosclerotic Cardiovascular Diseases

Yamashita T, Kasahara K, Emoto T, Matsumoto T, Mizoguchi T, Kitano N, Sasaki N, Hirata K. Circ J. 2015;79(9):1882-90. doi: 10.1253/circj.CJ-15-0526. Epub 2015 Jul 22.

Regulatory T cells and tolerogenic dendritic cells as critical immune modulators in atherogenesis

Sasaki N, Yamashita T, Kasahara K, Takeda M, Hirata K. Curr Pharm Des. 2015;21(9):1107-17. doi: 10.2174/1381612820666141013142518.

Anti-inflammatory and immune-modulatory therapies for preventing atherosclerotic cardiovascular disease

Yamashita T, Sasaki N, Kasahara K, Hirata K. J Cardiol. 2015 Jul;66(1):1-8. doi: 10.1016/j.jjcc.2015.02.002. Epub 2015 Mar 2.

Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice

Yodoi K, Yamashita T, Sasaki N, Kasahara K, Emoto T, Matsumoto T, Kita T, Sasaki Y, Mizoguchi T, Sparwasser T, Hirata K. Hypertension. 2015 Apr;65(4):889-95. doi: 10.1161/HYPERTENSIONAHA.114.04934. Epub 2015 Jan 19.

Regulatory/effector T-cell ratio is reduced in coronary artery disease

Emoto T, Sasaki N, Yamashita T, Kasahara K, Yodoi K, Sasaki Y, Matsumoto T, Mizoguchi T, Hirata K. Circ J. 2014;78(12):2935-41. doi: 10.1253/circj.cj-14-0644. Epub 2014 Oct 18.

CD3 antibody and IL-2 complex combination therapy inhibits atherosclerosis by augmenting a regulatory immune response

Kasahara K, Sasaki N, Yamashita T, Kita T, Yodoi K, Sasaki Y, Takeda M, Hirata K. J Am Heart Assoc. 2014 Apr 22;3(2):e000719. doi: 10.1161/JAHA.113.000719.

Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T-cell response in mice

Kita T, Yamashita T, Sasaki N, Kasahara K, Sasaki Y, Yodoi K, Takeda M, Nakajima K, Hirata K. Cardiovasc Res. 2014 Apr 1;102(1):107-17. doi: 10.1093/cvr/cvu002. Epub 2014 Jan 8.

Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice

Nakajima K, Yamashita T, Kita T, Takeda M, Sasaki N, Kasahara K, Shinohara M, Rikitake Y, Ishida T, Yokoyama M, Hirata K. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1963-72. doi: 10.1161/ATVBAHA.111.229443. Epub 2011 Aug 4.

The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images

Nakajima K, Yamashita T, Kita T, Takeda M, Sasaki N, Kasahara K, Shinohara M, Rikitake Y, Ishida T, Yokoyama M, Hirata K. J Cardiovasc Magn Reson. 2011 Oct 29;13(1):67. doi: 10.1186/1532-429X-13-67.